Optimising Early Respiratory Support for Preterm Infants: The HIPSTER Trial

Project Details

Every year in Australia more than 6000 premature babies need help to breathe. The sickest babies need help from a mechanical breathing machine, but many manage with a less aggressive technique called 'nasal CPAP', which uses short prongs in the nose. Nasal CPAP works quite well, but can be uncomfortable and damage the baby's nose. It requires a high level of nursing skill to manage and can interfere with feeding and bonding with parents. A newer, simpler breathing support is ‘High Flow’. This uses smaller prongs in the nose, causes less nasal damage, and is preferred by parents and nurses. We will perform an international, multi-center, randomized, controlled, non-inferiority trial of High Flow, compared with CPAP, as primary support to investigate whether High Flow is a safe alternative to nasal CPAP in supporting the breathing of premature babies from soon after birth.

The health economics unit will conduct the cost-effectiveness analysis of High Flow compared to NCPAP using trial data. Analyses will incorporate the cost of the device and the associated cost of hospital care from administrative databases. Results will be presented as a cost per additional treatment failure avoided for High Flow versus NCPAP at trial end, and will be determined following analysis of costs of device, costs of hospital care and effectiveness (treatment failure).


Dr Kim Dalziel

Dr Li Huang

Dr Calum T. Roberts

Dr Louise S. Owen

Dr Brett J Manley

Dr Dag Helge Frøisland

A/Prof Susan M. Donath

Prof Margo A. Pritchard

Dr David W. Cartwright

Dr Clare L. Collins

A/Prof Atul Malhotra

Prof Peter G. Davis



Research Group

Faculty Research Themes

Child Health

School Research Themes

Data science, health metrics and disease modeling

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Centre for Health Policy

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