The HOLISM Study

Project Details

A growing literature on the effects of lifestyle on the progression of multiple sclerosis (MS) highlights the potential benefit of diet, exercise, sun exposure and/or vitamin D, Omega-3 supplementation, and stress reduction. In the HOLISM study (Health Outcomes and Lifestyle In a Sample of people with Multiple Sclerosis) we aimed to recruit participants from online social media promoting lifestyle-based interventions in MS and examine in detail these factors, and determine their relationship to quality of life, relapse rate, physical function and disability. Around 2,500 participants who provided consent responded to an online questionnaire, providing demographic and disease-specific data as well as details of diet, exercise, sun exposure, vitamin D level and supplements, stress reduction techniques, medication use, and disability, using validated survey instruments, modified where necessary. Participants are followed at 2.5 year intervals in a longitudinal cohort study. Regression analyses have examined the predictors of functional status, depression risk, fatigue, sexual function, pain, cognitive function and quality of life from the demographic, lifestyle and medication factors, and their relative contributions. These data will assist in determining the association between lifestyle factors and health outcomes in people with MS, globally.

They will also help to inform future research, and advise people with MS of the potential contribution of lifestyle to their health-related quality of life and physical disability. There have been 15 publications from the HOLISM Study to date.

Researchers

A/Prof Sandra Neate

Dr Nupur Nag

A/Prof Tracey Weiland

Dr Steve Simpson-Yap

Dr Jeanette Reece

Maggie Yu

Honorary Prof George Jelinek

William Bevens, Research Assistant

Collaborators

Professor Jane Hocking, Head, Sexual Health Unit, MSPGH

Professor Fary Khan, Head, Australian Rehabilitation Research Centre

Dr Julie Campbell, Menzies Institute for Medical Research, University of Tasmania

Research Opportunities

This research project is available to PhD students, Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

Simpson-Yap S, Nag N, Jakaria M, Jelinek GA, Neate S. Sociodemographic and clinical characteristics of diet adherence and relationship with diet quality in an international cohort of people with multiple sclerosis. Mult Scler Relat Disord. 2021 Oct 3;56:103307. doi: 10.1016/j.msard.2021.103307.

Neate SL, Donald A, Jelinek GA, Nag N. Experiences of and attitudes to lifestyle modification for the management of multiple sclerosis: A qualitative analysis of free-text survey data. Health Expect. 2021 Oct 2. doi: 10.1111/hex.13364.

Bevens W, Gray K, Neate SL, Nag N, Weiland TJ, Jelinek GA, Simpson-Yap S. Characteristics of mHealth app use in an international sample of people with multiple sclerosis. Mult Scler Relat Disord. 2021 Sep;54:103092. doi: 10.1016/j.msard.2021.103092.

Simpson-Yap S, Nag N, Probst Y, Jelinek G, Neate S. Higher-quality diet and non-consumption of meat are associated with less self-determined disability progression in people with multiple sclerosis: A longitudinal cohort study. Eur J Neurol. 2021 Aug 14. doi: 10.1111/ene.15066.

Weiland TJ, Nag N, De Livera A, Jelinek GA, Neate SL, Bevens W, Simpson-Yap S. Two healthy lifestyle scores are associated with lower subsequent fatigue risk using inverse probability weighting in an international longitudinal cohort of people with multiple sclerosis. Eur J Neurol. 2021 Sep;28(9):2952-2964. doi: 10.1111

Simpson-Yap S, Jelinek P, Weiland T, Nag N, Neate S, Jelinek G. Self-reported use of vitamin D supplements is associated with higher physical quality of life scores in multiple sclerosis. Mult Scler Relat Disord* 2021;49:102760.

Neate SL, Taylor KL, Nag, N, Jelinek GA, Simpson S, Bevens W, Weiland TJ. Views of the Future of Partners of People with Multiple Sclerosis Who Attended a Lifestyle Modification Workshop: A Qualitative Analysis of Perspectives and Experiences. Int J Environ Res Public Health* 2021;18(1):85. 11pp.

Fidao A, De Livera A, Nag N, Neate S, Jelinek GA, Simpson-Yap S. Depression mediates the relationship between fatigue and mental health-related quality of life in multiple sclerosis. Mult Scler Relat Disord* 2021;47:102620.P10. Lin X, Yu M, Jelinek GA, Simpson-Yap S, Neate S, Nag N.

Greater Engagement with Health Information Is Associated with Adoption and Maintenance of Healthy Lifestyle Behaviours in People with MS. Int J Environ Res Public Health* 2020;17(16):5935.

Wu J, Jelinek GA, Weiland T, Hedström AK, Alfredsson L, Neate S, De Livera AM, Nag, N, Simpson-Yap, S. Perceived cognitive impairment is associated with sexual dysfunction in people with multiple sclerosis: A 2.5-year follow-up study of a large international cohort. Mult Scler Relat Disord* 2020;45:102410.

SL Neate, KL Taylor, GA Jelinek, AM De Livera, S Simpson, Jr, W Bevens, TJ Weiland. On the path together: Experiences of partners of people with multiple sclerosis of the impact of lifestyle modification on their relationship. 2019 Health & social care in the community 27 (6), 1515-1524

EL O'Kearney, CR Brown, GA Jelinek, SL Neate, KT Taylor, W Bevens, AM De Livera, S Simpson Jr, TJ Weiland. Mastery is associated with greater physical and mental health-related quality of life in two international cohorts of people with multiple sclerosis. 2019. Multiple sclerosis and related disorders, 101481.

Claudia H Marck, Zoe Aitken, Steve Simpson Jr, Tracey J Weiland, George A Jelinek. Does a modifiable risk factor score predict disability worsening in people with multiple sclerosis? MSJ Experimental, Translational and Clinical; 2019; 5(4)

Claudia H Marck, Alysha M De Livera, Tracey J Weiland, Pia L Jelinek, Sandra L Neate, Chelsea R Brown, Keryn L Taylor, Fary Khan, George A Jelinek. Pain in people with multiple sclerosis: Associations with modifiable lifestyle factors, fatigue, depression, anxiety, and mental health quality of life. Frontiers in neurology. 2017; 8, 461.

Marck CH, Neate SL, Taylor KL, Weiland TJ, Jelinek GA. Prevalence of Comorbidities, Overweight and Obesity in an International Sample of People with Multiple Sclerosis and Associations with Modifiable Lifestyle Factors. PLoS One. 2016;11(2):e0148573.

Marck CH, Jelinek PL, Weiland TJ, et al. Sexual function in multiple sclerosis and associations with demographic, disease and lifestyle characteristics: a cross-sectional international study. BMC Neurol. 2016;16:210.

Jelinek GA, De Livera AM, Marck CH, et al. Associations of Lifestyle, Medication, and Socio-Demographic Factors with Disability in People with Multiple Sclerosis: An International Cross-Sectional Study. PLoS One. 2016;11(8):e0161701.

Jelinek GA, De Livera AM, Marck CH, et al. Lifestyle, medication and socio-demographic determinants of mental and physical health-related quality of life in people with multiple sclerosis. BMC Neurol. 2016;16(1):235.

Weiland TJ, Jelinek GA, Marck CH, et al. Clinically significant fatigue: prevalence and associated factors in an international sample of adults with multiple sclerosis recruited via the internet. PLoS One. 2015;10(2):e0115541.

Jelinek GA, Weiland TJ, Hadgkiss EJ, Marck CH, Pereira N, van der Meer DM. Medication use in a large international sample of people with multiple sclerosis: associations with quality of life, relapse rate and disability. Neurol Res. 2015;37(8):662-673.

Jelinek GA, Marck CH, Weiland TJ, Pereira N, van der Meer DM, Hadgkiss EJ. Latitude, sun exposure and vitamin D supplementation: associations with quality of life and disease outcomes in a large international cohort of people with multiple sclerosis. BMC Neurol. 2015;15:132.

Hadgkiss EJ, Jelinek GA, Weiland TJ, Pereira NG, Marck CH, van der Meer DM. The association of diet with quality of life, disability, and relapse rate in an international sample of people with multiple sclerosis. Nutr Neurosci. 2015;18(3):125-136.

Hadgkiss EJ, Jelinek GA, Taylor KL, et al. Engagement in a program promoting lifestyle modification is associated with better patient-reported outcomes for people with MS. Neurol Sci. 2015;36(6):845-852.

Weiland TJ, Hadgkiss EJ, Jelinek GA, Pereira NG, Marck CH, van der Meer DM. The association of alcohol consumption and smoking with quality of life, disability and disease activity in an international sample of people with multiple sclerosis. J Neurol Sci. 2014;336(1-2):211-219.

Taylor KL, Hadgkiss EJ, Jelinek GA, et al. Lifestyle factors, demographics and medications associated with depression risk in an international sample of people with multiple sclerosis. BMC Psychiatry. 2014;14:327.

Marck CH, Hadgkiss EJ, Weiland TJ, van der Meer DM, Pereira NG, Jelinek GA. Physical activity and associated levels of disability and quality of life in people with multiple sclerosis: a large international survey. BMC Neurol. 2014;14:143.

Levin AB, Hadgkiss EJ, Weiland TJ, et al. Can meditation influence quality of life, depression, and disease outcome in multiple sclerosis? Findings from a large international web-based study. Behav Neurol. 2014;2014:916519.

Jelinek GA, Hadgkiss EJ, Weiland TJ, Pereira NG, Marck CH, van der Meer DM. Association of fish consumption and Omega 3 supplementation with quality of life, disability and disease activity in an international cohort of people with multiple sclerosis. Int J Neurosci. 2013;123(11):792-800.

Hadgkiss EJ, Jelinek GA, Weiland TJ, Pereira NG, Marck CH, van der Meer DM. Methodology of an International Study of People with Multiple Sclerosis Recruited through Web 2.0 Platforms: Demographics, Lifestyle, and Disease Characteristics. Neurol Res Int. 2013;2013:580596.

Research Group

Neuroepidemiology



Faculty Research Themes

Neuroscience

School Research Themes

Prevention and management of non-communicable diseases (including cancer), and promotion of mental health



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Centre for Epidemiology and Biostatistics

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