Optimal design of antimalarial population pharmacokinetic-pharmacodynamic studies


Project Details

The aim of this project was to improve the treatment of malaria by designing robust and efficient population pharmacokinetic studies that will ensure precise characterisation of the drug concentration-time profile for all patients suffering from malaria using our knowledge of antimalarial drugs and of the statistical methods used to analyse data from population pharmacokinetic studies.

The contribution of inadequate dose and frequency of administration of the antimalarial drug to malaria-related morbidity and mortality has been underappreciated. Recent developments in statistical methodology allow the pharmacokinetic profile of a drug to be derived from young children and pregnant women with less intense blood sampling but only when the blood-sampling schedule of the pharmacokinetic study has been properly designed. Studies using these new statistical methods and less intense blood sampling are called population pharmacokinetic studies.  The design of these population pharmacokinetic studies, however, is not straightforward. The number and timing of blood samples per patient and the total number of patients need careful consideration to ensure the proposed study designs are efficient and robust.


Associate Professor Julie Simpson

Dr Sophie Zaloumis

Professor Ric Price (Oxford University)


NHMRC Project Grant (2009-2011)

Research Group


Faculty Research Themes

Infection and Immunology

School Research Themes

Data science, health metrics and disease modeling

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Centre for Epidemiology and Biostatistics

Unit / Centre


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