Alexandra Stewart

The role of cytochrome polymorphisms in primaquine metabolism and effects on its activity in radical cure of Plasmodium vivax infection

Alexandra 2023Thesis title

The role of cytochrome polymorphisms in primaquine metabolism and effects on its activity in radical cure of Plasmodium vivax infection

Description of PhD Project

My PhD project will investigate the role of genetic polymorphisms in the metabolism of primaquine. Primaquine is the only antimalarial medication that targets the liver stage of Plasmodium vivax malaria. Without radical cure (treatment of both the blood and liver stages of P. vivax) individuals are at risk of recurrent episodes of malaria, which can result in significant morbidity. My fieldwork will take place in Madagascar, a malaria endemic region with significant population admixture and diversity. Research in this field requires repeated blood draws, however, there is limited information on the cultural significance of blood in Madagascar and use in research projects. Therefore, an additional component of my PhD project will be focused on community perceptions of malaria and blood collection for research studies. This research aims to provide insights into the intersection of blood collection and research, with a view to improving community consultation, engagement and participant involvement in studies involving biospecimen collection.

Supervisors

  • Professor Cathy Vaughan
  • Professor James McCarthy
  • Professor Peter Zimmerman

Biography

Alex is an infectious diseases physician and a graduate researcher. She has a background in global health, having previously completed the Diploma of Tropical Medicine and Hygiene and a Master of International Public Health, and has utilised her skills in a variety of contexts in Australia and overseas (Myanmar, South Sudan and Ethiopia). She is undertaking a part-time PhD and combining this with clinical work as an infectious diseases physician.

Funding/scholarships

  • NHMRC Postgraduate Scholarship