The Health Economics Unit (HEU) leads a program of research in measurement and use of health outcomes in making decisions about budget allocations and priority setting. Our work includes the development of methods for the measurement and valuation of benefits used in Health Technology Assessment (HTA).
Professor Nancy Devlin is a leading international expert focused on measuring and valuing health related quality of life; in particular, the challenges of valuing children’s health to improve evidence on effectiveness and cost effectiveness of children’s health care. The HEU have many projects that seek to improve how we measure and value health related quality of life (HRQoL) including a special emphasis on children. The HEU’s flagship project is the QUOKKA RESEARCH PROGRAM- QUality OF Life in Kids: Key evidence to strengthen decisions in Australia comprising 6 research projects and collaborations across 5 Australian universities and with international experts.
Our research on outcome measurement and valuation spans:
- Assessing acceptability, feasibility and validity of HRQoL in different populations using psychometric methods, including a focus on children (QUOKKA Project 1)
- Use of Patient Reported Outcome Measures (PROMs) in clinical settings (Renee Jones PhD)
- Development and adaptation of preference-based health-related quality of life (HRQoL) measures, including adaptation of the EQ-5D-Y for children aged 2-4 years
- Conducting valuation studies and advancing valuation methodology, including the derivation of utility values
- Use of HRQoL information to generate Quality Adjusted life Years (QALYs) as part of economic evaluations and estimation of cost-effectiveness to inform priority setting decisions
- Exploring the social value of a QALY
- Comparing child and adult QALYs (QUOKKA Project 6)
- Understanding complex relationships between health care treatments, health status, and quality of life and wellbeing
- The role of health and wellbeing outcomes, including utilities, in Health Technology Appraisal (HTA) and in evaluations across the public sector (including social care and aged care).
- Mapping between HRQoL instruments
- Systematic review and meta-analysis of utility values
QUOKKA QUality OF Life in Kids: Key evidence to strengthen decisions in Australia
EQ-HWB Collaborations to develop, value and test the new EuroQol instrument; EQ-HWB (Health and Wellbeing)
Randomised equivalence study to compare online interviews versus face-to-face interviews to value the EQ-5D-5L using Time Trade Off: Australian arm (HEU News)
Systematic Review of the Effect of a 1-Day versus 7-Day recall duration on patient reported outcome measures and HRQoL
HRQoL and genomics including impacts on carers
Development and Validation of a Preference-Based Index for the PedsQL (PedsUtil). PhRMA Foundation Value Assessment Research Awards, US
EuroQoL: Testing EQ-5D-Y for use in children aged 2-5 years (HEU News)
EuroQoL: Conceptual and empirical challenges for Using EQ-5D-Y values in economic evaluation (HEU News)
EuroQoL: Exploring the use of EQ-5D-3L in measuring population health in China (HEU News)
EuroQoL: Supporting the use of EQ-5D instruments in China
EuroQol: An Australian Value Set for the EQ-5D-Y
Related research staff:
Peasgood, T., Mukuria, C., Rowen, D., Tsuchiya, A., & Wailoo, A. (2022). Should We Consider Including a Value for "Hope" as an Additional Benefit Within Health Technology Assessment?. Value in health: S1098-3015(22)00148-6. Advance online publication. https://doi.org/10.1016/j.jval.2022.03.006
Carlton J, Peasgood T, Mukuria C, Connell J, Brazier J, Ludwig K, Marten O, Kreimeier S, Engel L, Belizán M, Yang Z. Generation, Selection, and Face Validation of Items for a New Generic Measure of Quality of Life: The EQ-HWB. Value in Health. 2022 Apr 1;25(4):512-24.
Brazier J, Peasgood T, Mukuria C, Marten O, Kreimeier S, Luo N, Mulhern B, Pickard AS, Augustovski F, Greiner W, Engel L. The EQ Health and Wellbeing: overview of the development of a measure of health and wellbeing and key results. Value in Health. 2022 Mar 8.
Carlton J, Peasgood T, Mukuria C, Johnson J, Ogden M, Tovey W. The role of patient and public involvement and engagement (PPIE) within the development of the EQ Health and Wellbeing (EQ-HWB). Journal of Patient-Reported Outcomes. 2022 Dec;6(1):1-8.
Mukuria C, Connell J, Carlton J, Peasgood T, Scope A, Clowes M, Rand S, Jones K, Brazier J. Qualitative Review on Domains of Quality of Life Important for Patients, Social Care Users, and Informal Carers to Inform the Development of the EQ Health and Wellbeing. Value in Health. 2022 Jan 13.
Peasgood T, Mukuria C, Brazier J, Marten O, Kreimeier S, Luo N, Mulhern B, Greiner W, Pickard AS, Augustovski F, Engel L. Developing a New Generic Health and Wellbeing Measure: Psychometric Survey Results for the EQ Health and Wellbeing. Value in Health. 2022 Jan 13.
Devlin,N., Pan, T., Kreimeier,S., Verstraete, J., Stolk, E., Rand,K., Herdman, M. Valuing EQ-5D-Y: the current state of play. Health and Quality of Life Outcomes, 2022 (forthcoming)
Xiong X, Dalziel K, Carvalho N, Xu R, & Huang L. Association between 24-hour movement behaviors and health-related quality of life in children. Qual Life Res, 2022, 31:231–240. https://doi.org/10.1007/s11136-021-02901-6
O’Loughlin R, Hiscock H, Pan T, Devlin N, Dalziel K. The relationship between physical and mental health multimorbidity and children’s health-related quality of life. Quality of Life Research. 2022, 31:2119–2131.
Mpundu-Kaambwa C, Balamu N, Lines L, Chen G, Dalziel K, Devlin N, Ratcliffe J. A Systematic Review of International Guidance for Self-Report and Proxy Completion of Child-Specific Utility Instruments. Value in Health, 3 June 2022.
Devlin N. Valuing Child Health Isn’t Child’s Plan. Value in Health. 2022, 3rd June.
Kwon J, Freijser L, Huynh E, Howell M, Chen G, Khan K, Daher S, Roberts N, Harrison C, Smith S, Devlin N, Howard K, Lancsar E, Bailey C, Craig J, Dalziel K, Hayes A, Mulhern B, Wong G, Ratcliffe J, Petrou S. Systematic Review of Conceptual, Age, Measurement and Valuation Considerations for Generic Multidimensional Childhood Patient-Reported Outcome Measures. PharmacoEconomics. 2022, 40(4):477-78.
Peasgood T, Mukuria C, Carlton J, Connell J, Devlin N, Jones K, Lovett R, Naidoo B, Rand S, Rejon-Parrilla JC, Rowen D. What is the best approach to adopt for identifying the domains for a new measure of health, social care and carer-related quality of life to measure quality-adjusted life years? Application to the development of the EQ-HWB. The European Journal of Health Economics. 2021. Apr 28:1-5.
Peasgood T, Chang J Y, Mir R, Mukuria C, Powell P A. The role of response domain and scale label in the quantitative interpretation of patient-reported outcome measure response options. Quality of Life Research, 2021. 30:2097–2108 https://doi.org/10.1007/s11136-021-02801-9
Peasgood T, Mukuria C, Carlton J, Connell J, Brazier J. Criteria for item selection for a preference-based measure for use in economic evaluation. Quality of Life Research, 2021 May;30(5):1425-1432 https://doi.org/10.1007/s11136-020-02718-9
Pan, T., Mulhern, B., Viney, R., Norman, R., Tran-Duy, A., Hanmer, J., Devlin, N. (2021). Evidence on the relationship between PROMIS-29 and EQ-5D: A Literature Review. Quality of Life Research. https://doi.org/10.1007/s11136-021-02911-4
Pan, T., Mulhern, B., Viney, R., Norman, R., Hanmer, J., Devlin, N. A Comparison of PROPr and EQ-5D-5L Value Sets. PharmacoEconomics (2021). https://doi.org/10.1007/s40273-021-01109-3
Dalziel K, Catchpool M, Garcia-lorenzo B, Gorostiza I, Norman R, Rivero-Arias O. Feasibility, Validity and Differences in Adolescent and Adult EQ‑5D‑Y Health State Valuation in Australia and Spain: An Application of Best–Worst Scaling. PharmacoEconomics, 2020: 38:499-513.
Carlton J, Peasgood T, Khan S, Barber R, Bostock J, Keetharuth AD. (2020) An emerging framework for fully incorporating public involvement (PI) into patient-reported outcome measures (PROMs). Journal of Patient-Reported Outcomes. Dec 1;4(1):4.
Peasgood T, Bhardwaj A, Brazier J E, Biggs K, Coghill D, Daley D, ... & Sonuga-Barke E J. What Is the Health and Well-Being Burden for Parents Living With a Child With ADHD in the United Kingdom?. Journal of Attention Disorders, 2020. 1087054720925899.
Schulz A, Jain M, Butt T, Ballinger R, Eliasson L, Macey J, Peasgood T, Olaye A, Terzakis-Snyder IA, Dyck I, West A. The Challenges of Living with and Caring for a Child or Children Affected by Neuronal Ceroid Lipofuscinosis Type 2 Disease: In-Depth Family Surveys in the United Kingdom and Germany. Journal of Inborn Errors of Metabolism and Screening. 2020 May 18;8.
Catchpool M, Ramchand J, Hare DL, Martyn M, Goranitis I. Mapping the Minnesota Living with Heart Failure Questionnaire (MLHFQ) onto the Assessment of Quality of Life 8D (AQoL-8D) utility scores. Qual Life Res. 2020 Oct;29(10):2815-2822. doi: 10.1007/s11136-020-02531-4. Epub 2020 May 18. PMID: 32424804.
McLoughlin C, Goranitis I, Al-Janabi H. Validity and Responsiveness of Preference-Based Quality-of-Life Measures in Informal Carers: A Comparison of 5 Measures Across 4 Conditions. Value Health. 2020 Jun;23(6):782-790. doi: 10.1016/j.jval.2020.01.015. Epub 2020 May 11. PMID: 32540237; PMCID: PMC7532692.
Wu Y, Al-Janabi H, Mallett A, Quinlan C, Scheffer IE, Howell KB, Christodoulou J, Leventer RJ, Lockhart PJ, Stark Z, Boughtwood T, Goranitis I. Parental health spillover effects of paediatric rare genetic conditions. Qual Life Res. 2020 Sep;29(9):2445-2454. doi: 10.1007/s11136-020-02497-3. Epub 2020 Apr 7. PMID: 32266555.
Peasgood T, Carlton J., Brazier J. A Qualitative Study of the Views of Health and Social Care Decision-makers on the Role of Wellbeing in Resource Allocation Decisions in the UK. 2019. Economies, 7(14). 1-14 https://doi.org/10.3390/economies7010014
Peasgood T, Foster D, Dolan P. Priority setting in healthcare through the lens of happiness. Global Happiness and Well-Being Policy Report. 2019. 26-51 https://s3.amazonaws.com/ghwbpr-2019/UAE/GH19_Ch3.pdf