Safety and immunogenicity of dTpa vaccine administered in pregnancy
A phase IV, observer-blind, placebo-controlled and randomised study will be conducted to assess the safety and immunogenicity of dTpa vaccine given during 27-36 weeks of gestation in healthy women aged 18-45 years. We aim to demonstrate that the immunogenicity of a single dose of dTpa vaccine is superior to controls in terms of pertussis antibodies, in the cord blood sample. Safety wil also be evaluated.
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