Colon Cancer Family Registry Cohort

Project Details

The CCFRC has served as an international resource for studies of the genetics and epidemiology of colorectal cancer (CRC) since 1997. It is the largest resource in the world for the study of CRC (and other cancers, such as endometrial cancer, that occur in these families). The CCFRC has supported and enabled over 200 scientific projects, many including collaborations with other top CRC groups in the world, that range from etiological to behavioral to clinical studies and has generated over 200 publications to date.

The aims for the next 5 years are to:

  1. Follow-up the cohort to update personal and family history of cancer, and risk factors
  2. Continue to test the cohort for genetic mutations and further characterize the pathology and genetic mutations of tumours 
  3. Enhance the cohort with additional clinical data 
  4. Continue to expand the use of the CCFRC resource through active collaborations with the larger scientific community.

Project summary

The Colon Cancer Family Registry Cohort is comprised of approximately 40,000 people with and without CRC from 10,000 families. Existing standardized data from the cohort include baseline and follow-up lifestyle and demographic risk factor questionnaires, clinical data, blood samples, tumor blocks, comprehensive genotype data, including genome-wide association study (GWAS) data and molecular characterisation of the tumours.  Families have been participants have been recruited from Australia, New Zealand, the USA and Canada via six institutions: The University of Melbourne, the Mayo Clinic, Cancer Care Ontario, the University of Hawaii, University of Southern California, and the Fred Hutchinson Cancer Research Center (Seattle).  The Informatics Centre for the CCFRC is in the Centre for Epidemiology and Biostatistics, The University of Melbourne and the biorepository for the Australasian samples is in the Department of Pathology, The University of Melbourne.

Researchers

Professor Mark Jenkins

Professor John Hopper

Dr Aung Ko Win

Dr Dan Buchanan (Department of Pathology, Melbourne Medical School, The University of Melbourne)

Associate Professor Louise Keogh

Professor Finlay Macrae (Royal Melbourne Academic Centre, Melbourne Medical School, The University of Melbourne)

Professor Ingrid Winship (Melbourne Health)

Dr Robert Haile (Stanford University)

Dr Laney Lindor (Mayo Clinic)

Funding

National Institutes of Health (USA)

Research Group

Colorectal Cancer



Faculty Research Themes

Cancer

School Research Themes

Prevention and management of non-communicable diseases (including cancer), and promotion of mental health, Screening and early detection of disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Centre for Epidemiology and Biostatistics